Characteristics of Chinese Families in Which Children and Both Parents Are Diagnosed with Malignant Tumors: A Retrospective Study

Objective To characterize Chinese families in which both parents and at least one child are diagnosed with malignant diseases provide reference for cancer screening or early detection people whose cancer. Methods Medical records of all clients to the center prevention National Cancer Center/Cancer Hospital between January 2008 February 2018 were screened select diseases. The profiles fathers, mothers, sons daughters, their age distribution diagnosis, similarity cancers two generations analyzed. proportions each males females cohort compared corresponding data from Center Registry China (NCCRC) 2013. Results Totally 135 identified 33 200 clients. Proportion lung fathers (40/135, 29.6%) mothers (38/135, 28.1%) higher than national (23.9% 14.9% females, respectively). proportion breast daughters (35/109, 32.1%) was that (14/135, 10.4%) (17.1%). In 71 father-son pairs cancer, 46.5% (33/71) same systematic disease, 16.9% (12/71) These indexes 31.2% (n=34) 10.1% (n=11), respectively 109 father-daughter 36.6% (n=26) 8.5% (n=6) mother-son 20.2% (n=20) mother-daughter Sons more likely suffer originated system as father's (χ2=4.299, P Conclusions For examinations should cover a full range rather father mother have suffered, stemmed parent's cancers. We suggest program these special population start earlier general population, emphasis on derived digestive women-specific cancers, i.e., ovarian cervical uterine females.